Medetomidine palm card

Written By PDPH SUPHR
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Medetomidine, or “rhino tranq,” is a veterinary sedative that is stronger than xylazine.

Medetomidine has been found in most of the dope samples in Philly.

Medetomidine can cause deep sleep or sleepiness for a long time, low blood pressure, and shaking.

Medetomidine withdrawal can start quickly and be very serious. Sometimes people need to go to the hospital.

Medetomidine withdrawal can cause:

  • a very fast heartbeat

  • very high blood pressure

  • going in and out of responding or being aware even while awake

  • heavy sweating

  • shaking or twitching

  • anxiety and restlessness

Signs to go to the hospital:

  • can’t stop throwing up

  • have chest pain

  • going in and out of responding or being aware, even while awake

  • otherwise experiencing more severe withdrawal symptoms than usual

Guidance for healthcare providers treating medetomidine withdrawal

Treating medetomidine withdrawal requires treating fentanyl withdrawal with long-acting opioid agonists like methadone and using adjunctive medications such as:

  • clonidine

  • guanfacine

  • tizanidine

  • dexmedetomidine

  • ketamine

  • olanzapine

  • hydroxyzine

  • benzodiazepines

  • prochlorperazine

  • chlorpromazine

Find current treatment guidance for medetomidine withdrawal from the Philadelphia Department of Public Health at: SubstanceUsePhilly.com/medetomidine

This card was created in June 2025. Check SubstanceUsePhilly.com for up-to-date treatment info.

PDPH SUPHR
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